Nucleic acids, peptides and carbohydrates are biopolymers that play essential roles in a wide array of biological processes. The same holds for naturally occurring conjugates of these molecules. To elucidate the mechanism of action of these molecules at a molecular level and ultimately modulate the biological processes in which they are involved, our group is focused on the development of synthetic approaches to (modified) oligomers and corresponding conjugates of these biopolymers. The development of new glycosylation procedures, phosphorylation methods, conjugation techniques and protective group manipulations are examples of synthetic approaches that are elaborated to attain structurally well-defined target molecules. The biological evaluation is carried out in collaboration with international renowned research groups.
Discover the world at Leiden University