Research

Introduction

The Leiden Institute of Chemistry houses the research groups in Chemistry and Life Sciences. Our environment and quality of life is largely determined by chemistry, therefore research at the forefront of molecular and life sciences is of high importance for our future.

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Research groups

Bio-organic Synthesis
Binding pocket of the HLA-DQ2 molecule

The research in the Biosyn-group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop synthetic methodology or as an inspiration for mimetic design.

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Biophysical Structural Chemistry
Biophysical Structural Chemistry

Research within our group revolves around the atomic structures of large bio-molecules and their complexes.

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Catalysis and Surface Chemistry
CASC

The research aim of the Surface Chemistry and Catalysis group is to probe and understand chemical reactions on well-defined, mostly single crystalline, surfaces at the molecular level. The group combines state-of-the-art experimental setups to study surface catalytic reactions using a variety of spectroscopic techniques, both at the metal-uhv and metal-liquid interface, with computational techniques based on density functional theory and dynamic Monte Carlo simulations.

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Metals in Catalysis, Biomimetics & Inorganic Materials
Ruthenium complex bound to biotin

Research at MCBIM, the inorganic chemistry group of the LIC, involves chemistry taking place within the coordination sphere of metal ions such as copper(II), iron(II), ruthenium(II), or europium(III).

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Protein Chemistry
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The research is aimed at understanding protein structure and function. Particular interests comprise protein-protein interactions & enzyme function (Prof. Ubbink), and drug discovery technologies (Dr. Siegal).

The section houses equipment for recombinant protein production and a variety biophysical characterisation methods and hosts the spin-out company ZoBio.

Solid State NMR/Biophysical Organic Chemistry
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The long term goal of our group is to reach understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices, medicine, and new materials of technical importance.

Supramolecular & Biomaterials Chemistry
Soft Matter Chemistry

The research in the Supramolecular & Biomaterials Chemistry group concerns both theoretical fundamentals and applications of supramolecular chemistry and chemical bio-nanotechnology. Research topics are: (a) model systems for lipid membrane fusion inspired by SNARE proteins, (b) drug delivery systems based on hydrogels and silica nanoparticles, and (c) models for protein-membrane complexes in photosynthesis.

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Theoretical Chemistry
Theoretical Chemistry

The main goal of the Theoretical Chemistry group, is to achieve the ability to predict the outcome of chemical reactions involving hydrogen from first principles. This goal is important in almost all fields of chemistry and in many fields of physics.

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