Mesoscale Modulation of Supramolecular Ureidopyrimidinone-Based Poly(ethylene glycol) Transient Networks in Water

TitleMesoscale Modulation of Supramolecular Ureidopyrimidinone-Based Poly(ethylene glycol) Transient Networks in Water
Publication TypeJournal Article
Year of Publication2013
AuthorsKieltyka, R.E., A.C.H. Pape, L. Albertazzi, Y. Nakano, M.M.C. Bastings, I.K. Voets, P.Y.W. Dankers, E.W. Meijer
JournalJournal of the American Chemical Society
Volume135
Issue30
Pagination11159-11164
Date PublishedJul 31
ISBN Number0002-7863
Accession NumberWOS:000322752900047
Keywordsgels, hydrogels, molecular recognition, peptide, shape, system
Abstract

In natural systems, highly synergistic non-covalent interactions among biomolecular components exert mesoscopic control over hierarchical assemblies. We herein present a multicomponent self-assembly strategy to tune hierarchical supramolecular polymer architectures in water using highly affine and directional ureidopyrimidinone-poly-(ethylene glycol)s (UPy-PEG). Using scattering methods and oscillatory rheology, we observe the structural and mechanical regulation of entangled monofunctional UPy-PEG fibrils by cross-linking bifunctional UPy-PEG fibrils. This supramolecular mixing approach opens the door to a range of subtly distinct materials for chemical and biological applications.

DOI10.1021/Ja403745w
Alternate JournalJ Am Chem Soc

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