Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-alpha in Brain

TitleDevelopment of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-alpha in Brain
Publication TypeJournal Article
Year of Publication2013
AuthorsBaggelaar, M.P., F.J. Janssen, A.C.M. van Esbroeck, H. den Dulk, M. Allara, S. Hoogendoorn, R. McGuire, B.I. Florea, N. Meeuwenoord, H. van den Elst, G.A. van der Marel, J. Brouwer, V. Di Marzo, H.S. Overkleeft, M. van der Stelt
JournalAngewandte Chemie-International Edition
Volume52
Issue46
Pagination12081-12085
Date PublishedNov 11
ISBN Number1433-7851
Accession NumberWOS:000326670800029
Keywordsacid amide hydrolase, activity-based probe, biosynthesis, drug discovery, endocannabinoid, endocannabinoid 2-arachidonoylglycerol, hydrolases, identification, modulators, potent inhibitors, proteomics, reversible inhibitors
DOI10.1002/Anie.201306295
Alternate JournalAngew Chem Int Edit

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