Activity-based protein profiling and bio-orthogonal chemistry

Activity-based protein profiling and bio-orthogonal chemistry

From 19-21 April the Activity-based protein profiling and bio-orthogonal chemistry (ABPP+BOC) conference meeting will be held at the Leiden Institute of Chemistry.

 

Contact

Bobby Florea b.florea@chem.leidenuniv.nl +31 6 487 18440
Mionne Laman m.m.h.laman@chem.leidenuniv.nl

Registration

Registration has now closed.

Wednesday April 19th
10:00 - 12:30   Arrival and registration
12:30 - 13:30   Lunch/Posters
13:30 - 13:35   Opening
13:35 - 14:00   Katarzyna Błażewska (Lodz University of Technology)
Finding the lead position in imidazo[1,2-a]pyridine ring for development of RGGT inhibitors derived from 3-IPEHPC
14:00 - 14:25   Theresa Manz (Christian Ducho lab)
Nucleoside Antibiotics and Their Interaction with The Bacterial and Human Proteome
14:25 - 14:50   Marjolein Soethoudt (van der Stelt Lab)
Detection of endogenous cannabinoid CB2 receptor expression using photo-affinity-based probes
 
14:50 - 15:05   Coffee/tea break
 
15:05 - 15:30   Florenci González (Universitat Jaume I)
Design and Synthesis of Cysteine Proteases Inhibitors
15:30 - 15:55   Tim van Kersavond (Steven Verhelst lab)
Synthesis and application of selective affinity-based probes for proteases
15:55 - 16:20   Martin Witte (University of Groningen)
Profiling the targets of enol cyclocarbamates electrophiles in mammalian and bacterial cells
16:20 - 16:45   Sander van Kasteren (Leiden University)
Correlative Light-Electron Microscopy To Study Enzyme Activities In Their Subcellular Context
 
17:00 - 18:00   COST meeting discussion for group leaders
 
  Free evening
Thursday April 20th
09:00 - 09:30   Welcome and coffee
09:30 - 09:55   Renier van den Hoorn (University of Oxford)
Bacterial plant pathogen inhibits secreted host beta galactosidase to prevent recognition
09:55 - 10:20   Markus Lakemeyer (Stephan Sieber lab)
Chemical manipulation of bacterial patho-genesis: Mechanism and inhibition of Caseinolytic Protease P
10:20 - 10:45   Özlem Dilek (Istanbul Kemerburgaz University)
Bioorthogonal fluorescent probes for targeting of cellular carbonylation in live cells
 
10:45 - 11:00   Coffee/tea break
 
11:00 - 11:25   Michael Meijler (Ben-Gurion University of the Negev)
Chemical Information Warfare between Species
11:25 - 11:50   Aisling Minard (Robin Bon lab)
Understanding the mode-of-action of TRPC4/5 ion channel inhibitors
11:50 - 12:15   Marthe Walvoort (University of Groningen)
Understanding the process of bacterial protein hyperglycosylation
 
12:15 - 12:20   Group photo
 
12:25 - 13:30   Lunch/Posters
 
13:30 - 13:55   Scott Lovell (Ed Tate lab)
The KLK Activome: identifying drug targets within a complex protein-interaction network
13:55 - 14:20   Misal G. Memeo (Paolo Quadrelli lab)
The Nitrile Oxides in Probes
14:20 - 14:45   Markus Kaiser (University of Duisburg-Essen)
Chemical biology/proteomics as a biological system-independent generic research approach
14:45 - 15:05   Kimberly Bonger (Radboud University)
Exploring vinylboronic acids as reactants in bioorthogonal chemistry
 
15:05 - 15:20   Coffee/tea break
 
15:05 - 15:30   Marta Artola Perez de Azanza (Herman Overkleeft lab)
Rational design of mechanism-based retaining α-glucosidase and α-galactosidase inhibitors
15:30 - 15:55   Katharina Witting (Huib Ovaa lab)
A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes
15:55 - 16:20   Sybrin Schröder (Herman Overkleeft lab)
Activity-based protein profiling: From exo- towards endo- glycosidases
16:20 - 16:45   Daniel Lahav (Herman Overkleeft lab)
Fluorescence polarization ABPP assay for discovery of inhibitors of human neutral glucosyl-ceramidase
 
17:00 - 20:00   Barbeque at the Gorlaeus Laboratories
Friday April 21st
09:00 - 09:30   Welcome and coffee
09:30 - 09:55   Megan Wright (University of Leeds)
Host-pathogen signalling: stealthy chemical probes reveal the bacterial receptor of a human hormone
09:55 - 10:20   Ethan Kuo (Hans Aerts lab)
Characterization of cyclophellitol- and cyclophellitol aziridine-derived activity-based probes targeting retaining glycosidases
10:20 - 10:45   Benedikt Kessler (Oxford University)
Ubiquitin -Omics for Target Discovery in Human Disease
 
10:45 - 11:00   Coffee/tea break
 
11:00 - 11:25   Liang Wu (Gideon Davies lab)
Activity Based Probes for Functional Interrogation of Human Heparanase
11:25 - 11:50   Xue Yang (IJzerman lab)
An affinity-based probe for the human adenosine A2A receptor
11:50 - 12:15   Annelot van Esbroeck (van der Stelt Lab)
Chemoproteomic Mapping of the BIA 10-2474 Interaction Landscape: Shedding Light on a Fatal Clinical Trial
 
12:15 - 13:30   Lunch/Posters
13:30   Closure
Participants include:

Florenci González Adelantado (Universitat Jaume I)Christian Ducho (Saarland University)
Robin Bon lab (University of Leeds): Hester Beard, Aisling Minard, Jacob Hauser
Steven Verhelst lab (KU Leuven): Tim Van Kersavond, Jian Yang 
Huib Ovaa lab (LUMC)
Mario vd Stelt lab (Leiden University)
Sander van Kasteren lab (Leiden University)
Hermen Overkleeft lab (Leiden University)
Özlem Dilek lab (Istanbul Kemerburgaz University)
Martin Witte lab (University of Groningen)
Ed Tate lab (Imperial College London): Remigiusz Serwa, Scott Lovell, Mladen Stojanovic
Stephan Sieber lab (Technical University of Munich): Markus Lakemeyer
Michael Meijler lab (Ben Gurion University of the Negev)
Paolo Quadrelli lab (University of Pavia): Misal G. Memeo, Mattia Moiola
Markus Kaiser lab (Universität Duisburg-Essen)
Kimberly Bonger lab (Radboud University)
Katarzyna Błażewska lab (Politechnika Łódzka)

Megan Wright (University of Leeds)

A list of (currently registered) attendees can be found here.

Accommodation

We have a special price agreement with Holiday Inn Leiden.
We kindly ask you to make a reservation by sending an e-mail to the hotel yourself to reservations@hileiden.com with the reference code: ABPP 2017.
A credit card number will be necessary as a guarantee for this booking and the usual conditions are applicable to your reservation.

There are various options:

  • € 103 for a superior room per night/1 ps use with check-in date 18 april 2017 and check-out date 21 april 2017
  • € 128 for a superior room per night/2 ps use with check-in date 18 april 2017 and check-out date 21 april 2017
  • € 103 for a superior room per night/1 ps use with check-in date 19 april 2017 and check-out date 21 april 2017
  • € 128 for a superior room per night/2 ps use with check-in date 19 april 2017 and check-out date 21 april 2017
  • € 120,50 for king room per night/1 ps use with check-in date 19 april 2017 and check-out date 22 april 2017
  • € 128 for a superior room per night/2ps use with check-in date 19 april 2017 and check-out date 22 april 2017

Included in the hotel fee are the following amenities:

  • breakfast
  • wifi
  • fitness, swimming pool and sauna access (so bring a bathing suit)
  • local city tax is excluded for all reservations, € 2,50 per person (20 years and older) per night
Transportation to/from hotel to Leiden city centre

In the morning and evening:
A free shuttle service (small bus max 8 ps) on working days from and to Leiden Central station in approximately 10 minutes. An extra stop at the Bio Science park is possible on request.
http://www.hileiden.com/en/parkingshuttle-service.html
This will be handy for transport to the diner on Thursday.

Transfer from Schiphol Airport to Holiday Inn hotel
Taxi De Groot:
€59,- taxi from Schiphol pick-up point to Holiday Inn Leiden
€69,- taxi from Schiphol gate to Holiday Inn Leiden

When reserved via De Groot the following can be followed:

  1. Directly after landing, call company De Groot to inform about the arrival +31 (0)71 512 33 00
  2. Inform De Groot about luggage (only carry-on or checked in bags)
  3. After passing the customs, please go upstairs to “Departures 2- door E”
  4. Go outside at door E(KLM departures) and cross the road to the outside lane and await your taxi
  5. Taxi De Groot can be recognized by the license plate numbers given over the phone

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